Abstract Search

ea0041ep600 | Endocrine tumours and neoplasia | ECE2016

Immunohistochemical study of AuroraB proves association with differentiation and expression of crucial progression markers in gastroenteropancreatic neuroendocrine neoplasms

Wang Yawen , Briest Franziska , Greshake Sonja , Lock Adrian , Horsch Dieter , Arnold Christian , Berg Erika , Hummel Michael , Siegmund Britta , Grabowski Patricia

Objective: Gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) are rare and heterogeneous in their tumor biology. Therapeutic options to prevent growth and dissemination are still not satisfactory. As shown previously, survivin and aurora kinases (members of the mitotic chromosomal passenger complex) play a role in cell cycle progression; FOXM1 is a transcription factor that regulates G2/M progression and is associated with grading and metastasis in GEP-NENs. Aurora kina...

0 shares

ePoster

Endocrine Abstracts

Immunohistochemical study of AuroraB proves association with differentiation and expression of crucial progression markers in gastroenteropancreatic neuroendocrine neoplasms

BiosciAbstracts